Introduction to resistance to anticancer agents

Urokinase receptor and resistance to targeted anticancer agents

The urokinase receptor (uPAR) is a GPI-anchored membrane protein, which regulates protease activity at the cell surface and, in collaboration with a system of co-receptors, triggers cell-signaling and regulates gene expression within the cell. In normal tissues, uPAR gene expression is limited; however, in cancer, uPAR is frequently over-expressed and the gene may be amplified. Hypoxia, which o...

Anticancer agents targeted to sirtuins.

Sirtuins are nicotinamide adenine dinucleotide+-dependent deacetylases of which there are seven isoforms (SIRT1-7). Sirtuin activity is linked to gene expression, lifespan extension, neurodegeneration, and age-related disorders. Numerous studies have suggested that sirtuins could be of great significance with regard to both antiaging and tumorigenesis, depending on its targets in specific signa...

واحدهای دستوری : فصل پنجم از کتاب introduction to theoretical linguistic (john lyons)

رساله حاضر ترجمه فصل پنجم از کتاب "مقدمه ای بر زبانشناسی نظری" اثر لاینز است . در این فصل سه واحد مختلف توصیف دستوری یعنی جمله، واژک [تکواژ] و واژه بررسی شده است . طبق اظهار بلومفیلد "جمله یک صورت زبانی مستقل است ، نه اینکه بوسیله هر گونه ساختمان دستوری در هر صورت زبانی بزرگتر گنجانیده شده باشد" . نکته اصلی تعریف وی را می توان به اختصار بصورت زیر بیان کرد: جمله بزرگترین واحد توصیف دستوری است که...

Marine Mollusk‐Derived Agents with Antiproliferative Activity as Promising Anticancer Agents to Overcome Chemotherapy Resistance

The chemical investigation of marine mollusks has led to the isolation of a wide variety of bioactive metabolites, which evolved in marine organisms as favorable adaptations to survive in different environments. Most of them are derived from food sources, but they can be also biosynthesized de novo by the mollusks themselves, or produced by symbionts. Consequently, the isolated compounds cannot...

Resistance and cross-resistance of Escherichia coli mutants to anticancer agents: nitrogen mustard and nitromin.